Prasugrel but Not High Dose Clopidogrel Overcomes the Lansoprazole Neutralizing Effect of P2y(12) Inhibition: Results of the Randomized Dosapi Study

Jean-Philippe Collet,Jean-Sébastien Hulot,Jérémie Abtan,Ghalia Anzaha,Mathieu Kerneis,Johanne Silvain,Guillaume Cayla,Stephen A. O’Connor,Olivier Barthélémy,Farzin Beygui,Sophie Galier,Delphine Brugier,Eric J. Stanek,Scott L. Charland,Vanessa Gallois,Gilles Montalescot, for the DOSAPI investigators.

European journal of clinical pharmacology（2014）

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摘要

The potential negative metabolic interaction between proton pump inhibitors and clopidogrel is an unsolved issue. We hypothesized that doubling the clopidogrel maintenance dose (150 mg) would be less effective than switching to prasugrel 10 mg maintenance dose (MD) to overcome this negative interaction.

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关键词

Thienopyridine,Proton pump inhibitor,Platelet reactivity,Coronary artery disease

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