Increased centrosome amplification in aged stem cells of the Drosophila midgut
Biochemical and Biophysical Research Communications（2014）
Abstract
•Increased centrosome amplification in ISCs of aged Drosophila midguts.•Increased centrosome amplification in ISCs of oxidative stressed Drosophila midguts.•Increased centrosome amplification in ISCs by overexpression of PVR, EGFR, and AKT.•Supernumerary centrosomes can be responsible for abnormal ISC polyploid cells.•Supernumerary centrosomes can be a useful marker for aging stem cells.
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Key words
Centrosome,Adult stem cell,Aging,PVR,EGFR,Drosophila midgut
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