Neuroprotective effects of diarylpropionitrile against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons.
Neuroscience Letters(2014)
摘要
•Treatment with DPN alleviated Aβ1–42-induced cell death and morphological changes.•DPN also reduced production of ROS induced by Aβ1–42.•DPN prevents Aβ1–42-induced toxicity by attenuating apoptosis and inflammation.•DPN effects may involve inhibition of JNK and p38 including activation of ERK1/2 and Akt.
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关键词
Alzheimer's disease,β-Amyloid peptide,Diarylpropionitrile,Antioxidant,Apoptosis,Anti-inflammation
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