FOXO1-dependent up-regulation of MAP kinase phosphatase 3 (MKP-3) mediates glucocorticoid-induced hepatic lipid accumulation in mice.
Molecular and Cellular Endocrinology（2014）
Abstract
•We examined the mechanism of Dex-promoted MKP-3 protein expression in cultured liver cells and in the liver of lean mice.•We demonstrated that FOXO1 is required for Dex-induced MKP-3 protein upregulation.•Global MKP-3 deficiency protected mice from developing Dex-induced metabolic disorders.
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Key words
MKP-3,Dex,FOXO1,GC,DUSP6,MAPK,ERK,PI3K,mTOR,DIO mice,VLDL,WT,TG,PPARγ,FAS,SCD1,ACC1,ACC2
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