Covalent, sequence-specific attachment of long DNA molecules to a surface using DNA-templated click chemistry.
CHEMICAL COMMUNICATIONS(2014)
Abstract
We present a novel method that covalently and sequence-specifically attaches long DNA molecules to a surface that is compatible with high-resolution atomic force microscopy (AFM) imaging. Surfaces prepared with this approach are ideally suited for performing biophysical experiments on single DNA molecules.
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Key words
long dna molecules,surface,sequence-specific,dna-templated
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