Methylxanthine reversal of opioid-induced respiratory depression in the neonatal rat: mechanism and location of action.

E V Mosca,P Ciechanski,A Roy,E C Scheibli,K Ballanyi,R J A Wilson

Respiratory Physiology & Neurobiology（2014）

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摘要

•Theophylline recovers neonatal breathing from DAMGO suppression.•Stimulation of breathing by theophylline is carotid body independent.•The main effect of theophylline is central, via phosphodiesterase inhibition.•Neonatal carotid body has A1 receptors that may contribute to hypoxic response.

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关键词

Neonate,Apnea,Prematurity,Methylxanthine,Carotid body

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