Cytotoxicity of compounds from the fruits of Derris indica against cholangiocarcinoma and HepG2 cell lines

Two new compounds, derrivanone ( 1 ) and derrischalcone ( 2 ), were isolated from the crude hexane extract of the fruits of Derris indica. In addition, 14 known compounds were isolated from the fruits of this plant. Chalcones 2 – 4 showed strong cytotoxicity against cholangiocarcinoma cell line (M156) and human hepatoma HepG2 cells. In addition, flavanones 15 and 16 exhibited potent and high cytotoxic efficacy.