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Effect of body position on ventricular CSF methotrexate concentration following intralumbar administration.

S M Blaney,D G Poplack,K Godwin,C L McCully,R Murphy,F M Balis

Journal of clinical oncology : official journal of the American Society of Clinical Oncology（1995）

Cited 47|Views6
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Abstract
Maintaining a prone position for 1 hour after an intralumbar dose increased the peak methotrexate concentration and drug exposure in ventricular CSF. CSF drug distribution following intralumbar therapy can be influenced by body position after the injection.
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