An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial-mesenchymal transition.

Chul-Yong Park,Kyung Nan Min,Jee-Yeon Son,So-Yeon Park,Jeong-Seok Nam,Dae-Kee Kim,Yhun Yhong Sheen

Cancer Letters（2014）

Cited 50|Views2

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Abstract

•IN-1130 inhibited Smad/TGF-β signaling, EMT, cell migration, and invasion.•IN-1130 inhibited lung metastasis of mammary tumor in mice models.•IN-1130 prolonged the life span of tumor bearing mice.

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Key words

Transforming growth factor-β (TGF-β),ALK5,IN-1130,Breast cancer,Metastasis

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