Full-Genome Sequence Of Human Betacoronavirus 2c Jordan-N3/2012 After Serial Passage In Mammalian Cells

Kenneth G Frey,Cassie L Redden,Kimberly A Bishop-Lilly,Reed Johnson,Lisa E Hensley,Kanakatte Raviprakash,Thomas Luke,Tad Kochel,Vishwesh P Mokashi,Gabriel N Defang

MICROBIOLOGY RESOURCE ANNOUNCEMENTS（2014）

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摘要

Middle East respiratory syndrome coronavirus (MERS-CoV) is the etiologic agent of a highly lethal pneumonia. Here, we report the full-genome sequence of the Jordan-N3/2012 strain after serial passage in two distinct mammalian cell lines. The genome exhibits noteworthy stability, which may inform the development of vaccines and therapeutics used to treat infection with this virus.

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