A Prospective Research Study Of Anti-Glaucoma Drugs Prescribing, Utilization Pattern And Adverse Drug Reaction Recording In A University Hospital

Objective: This study was carried out to evaluate the drug prescribing, utilization pattern and adverse drug reactions recording associated with drugs prescribed to glaucoma patients.Materials and Methods: A total of 50 glaucoma patients were included in the study, based on inclusion and exclusion criteria. All the observations were recorded in drug utilization and ADR recording documentation form.Results: Out of 50 patients suffering from glaucoma, 38 patients (76 %) were diagnosed open angle glaucoma, 4 patients (8 %) closed angle glaucoma and 8 patients (16 %) post-operative respectively. There were 19 patients (38 %) males and 31 patients (62 %) were females. The age range between 41-50 years had the maximum number of patients 15 (30 %). A total of 17 patients (34 %) had family history of glaucoma. Timolol was prescribed to 34 patients (68 %), followed by dorzolamide 18 patients (36 %) and acetazolamide 14 patients (28 %). A total of 32 patients (64 %) were prescribed single drug therapy whereas 18 patients (36 %) were on multiple drug therapy. A total of 25 patients (50 %) reported ADR. In the present study, latanoprost was associated with maximum number of ADRs 9 patients (18 %) followed by acetazolamide 7 patients (14 %), dorzolamide 4 patients (8 %), then timolol 3 patients (6 %) and pilocarpine 2 patients (4 %). According to Naranjo scale, in 6 patients (24 %) the ADR were unlikely, 12 patients (48 %) were given possible score, 3 patients (12 %) were given probable score, and 4 patients (16 %) were given definite scores.Conclusion: In the present study, the maximum patients were in the age group of 41-50 years. The most commonly prescribed drugs were timolol followed by dorzolamide, acetazolamide. Latanoprost was associated with maximum number of ADRs.