Assessment of the proliferative capacity of the flavanones 8-prenylnaringenin, 6-(1.1-dimethylallyl)naringenin and naringenin in MCF-7 cells and the rat mammary gland.

Janina Helle,Kristin Kräker,Manuela I Bader,Annekathrin M Keiler,Oliver Zierau,Günter Vollmer,JoEllen Welsh,Georg Kretzschmar

Molecular and Cellular Endocrinology（2014）

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摘要

•Naringenin type phytoestrogens bind ER subtypes with different affinities.•8-PN, 6-DMAN and Nar induce mitotic effects in MCF-7 cells.•8-PN and 6-DMAN treatment display proliferative effects on the mammary gland of rats.•Proliferative responses in the mammary gland are weak compared to E2 treatment.

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关键词

8-PN,6-DMAN,Nar,E2,ER,TEB,HRT,IGF-1,FGF,EGF,TGF-β,aERKO,bERKO,PGR,PRKO,CEE,ovx,FUL,RBA,Areg,Mki67,Pcna,Csn2,Rps18,EGFR

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