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Nanosuspension for the delivery of a poorly soluble anti-cancer kinase inhibitor.

Fabienne Danhier,Bernard Ucakar,Marie-Lyse Vanderhaegen,Marcus E Brewster,Tina Arien,Véronique Préat

European Journal of Pharmaceutics and Biopharmaceutics（2014）

Cited 18|Views9
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Abstract
•We evaluate the anti-cancer multi-targeted kinase inhibitor, MTKi-327.•Various nanomedicines have been compared for the delivery of MTKi-321.•Nanosuspension is the most effective anti-cancer MTKi-327 delivery system.•MTKi-327 nanosuspension enhances the administered dose and the MTD.•MTKi-327 was evaluated in vivo: anti-tumor efficacy and pharmacokinetic studies.
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AUC,CL,DMEM,EDTA,EGFR,EMA,EPR,FDA,HPLC,IV,LOQ,MTD,NMR,PCL,PDI,PEG,PK,PLGA,PTX,PVDF,RES,SEC,SEM,TMC,VEGFR
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