ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis

In this study, the authors show that TGF-β/ALK5 and JNK signaling is necessary during the late stages of adult neurogenesis to promote the survival, migration and proper morphology of newborn neurons. In addition, constitutive activation of this pathway is able to promote improved performance on spatial and contextual learning tasks.