Decreased levels of serum nesfatin-1 in patients with preeclampsia.

Context: Nesfatin-1 is implicated to possess an anti-inflammatory effect. Objective: The aim of our study is to investigate whether abnormal serum levels of nesfatin-1 are associated with the presence and severity of preeclampsia. Methods: A total of 120 women with preeclampsia and 92 women with uncomplicated pregnancies were enrolled in this study. Results: Women with preeclampsia showed significantly reduced levels of serum nesfatin-1 levels than women with uncomplicated pregnancies. Serum nesfatin-1 levels were significantly decreased in women with severe preeclampsia compared with women with mild preeclampsia. Conclusion: Decreased serum nesfatin-1 levels are associated with the presence and severity of preeclampsia.