Pro198Leu missense polymorphism of the glutathione peroxidase 1 gene might be a common genetic predisposition of distal symmetric polyneuropathy and macrovascular disease in Japanese type 2 diabetic patients.

Shohei Matsuno,Hideyuki Sasaki,Hiroshi Yamasaki,Hiroyuki Yamaoka,Kenichi Ogawa,Muneki Nakatani,Tohru Hamanishi,Asako Doi,Yoshio Nakano,Hisao Wakasaki,Hiroto Furuta,Masahiro Nishi,Takashi Akamizu,Kishio Nanjo

JOURNAL OF DIABETES INVESTIGATION（2011）

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摘要

Aims/Introduction: We have previously reported that the Pro198Leu missense polymorphism in the glutathione peroxidase 1 (GPx-1) gene was associated with frequent macrovascular disease (MVD). Our goal was to examine whether the GPx-1 genotype is associated with diabetic neuropathy.

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关键词

Glutathione peroxidase 1 gene,Diabetic distal symmetric polyneuropathy,Macrovascular disease

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