Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and prognostic indicator in patients with hepatitis B virus-associated hepatocellular carcinoma.
Clinical Biochemistry(2014)
Abstract
•Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) is associated with HCC development.•Serum ITIH4 levels are reduced in HCC compared to that in CHB and cirrhosis.•Low serum ITIH4 levels are associated with shorter survival in HCC patients.
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Key words
Inter-alpha-trypsin inhibitor heavy chain H4,Hepatitis B,Hepatocellular carcinoma,Survival,Diagnosis
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