Some Basic Aspects Of Hla-G Biology
JOURNAL OF IMMUNOLOGY RESEARCH(2014)
摘要
Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in exosomes. In this review we will focus on HLA-G biochemistry with special emphasis to the mechanisms that regulate its expression and how the protein modifications affect the quantification in biological fluids.
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关键词
solubility,ubiquitination,gene expression regulation,biology,expression,membrane proteins,exosomes
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