Intermediate-Type Vancomycin Resistance (Visa) In Genetically-Distinct Staphylococcus Aureus Isolates Is Linked To Specific, Reversible Metabolic Alterations
PLOS ONE(2014)
摘要
Intermediate (VISA-type) vancomycin resistance in Staphylococcus aureus has been associated with a range of physiologic and genetic alterations. Previous work described the emergence of VISA-type resistance in two clonally-distinct series of isolates. In both series (the first belonging to MRSA clone ST8-USA300, and the second to ST5-USA100), resistance was conferred by a single mutation in yvqF (a negative regulator of the vraSR two-component system associated with vancomycin resistance). In the USA300 series, resistance was reversed by a secondary mutation in vraSR. In this study, we combined systems-level metabolomic profiling with statistical modeling techniques to discover specific, reversible metabolic alterations associated with the VISA phenotype.
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关键词
principal component analysis,metabolomics,mass spectrometry,microbiology,dna binding proteins
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