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Structural and thermodynamic characterization of doxycycline/β-cyclodextrin supramolecular complex and its bacterial membrane interactions.

Diego F Suárez,Jessika Consuegra,Vivianne C Trajano,Sávio M L Gontijo,Pedro P G Guimarães,Maria E Cortés,Ângelo L Denadai,Rubén D Sinisterra

Colloids and Surfaces B: Biointerfaces（2014）

Cited 35|Views10
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Abstract
•Study of the DOX and DOX/βCD interactions with S. aureus and cellular viability.•Ion-pairing and hydrogen bonding interaction of DOX and the S. aureus membrane.•Adhesion synergic effect of DOX/βCD through hydrogen bonds.•DOX/βCD was found to be more active against S. aureus than pure DOX.•DOX/βCD induced cell proliferation and showed lower cytotoxicity than DOX.
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Key words
Doxycycline,β-Cyclodextrin,Antimicrobial,Membrane interactions,Susceptibility,Cytotoxicity
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