Safety and reactogenicity of BCG revaccination with isoniazid pretreatment in TST positive adults.

Mark Hatherill,Hendrik Geldenhuys,Bernadette Pienaar,Sara Suliman,Phalkun Chheng,Sara M Debanne,Daniel F Hoft,W Henry Boom,Willem A Hanekom,John L Johnson

Vaccine（2014）

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摘要

•The safety profile of live mycobacterial vaccines in TB infected adults is unknown.•BCG revaccination of adults with latent TB infection was safe and well tolerated.•Reactogenicity of BCG revaccination was unaffected by isoniazid pretreatment.•Trials of live mycobacterial vaccines may be considered in TB infected adults.

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关键词

BCG,Revaccination,Safety,LTBI,Isoniazid

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