Chemosensitization of rhabdomyosarcoma cells by the histone deacetylase inhibitor SAHA.

Cancer Letters（2014）

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摘要

•SAHA and chemotherapeutics synergize to trigger apoptosis in RMS.•SAHA and Doxorubicin change expression of pro- and antiapoptotic Bcl-2 proteins.•SAHA and Doxorubicin cooperate to activate Bax and Bak.•Bcl-2 overexpression inhibits SAHA/Doxorubicin-induced apoptosis.

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关键词

Apoptosis,Rhabdomyosarcoma,HDACI,Chemotherapy,Cell death

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