Dipeptidyl petidase-IV inhibitor (gemigliptin) inhibits tunicamycin-induced endoplasmic reticulum stress, apoptosis and inflammation in H9c2 cardiomyocytes.

•Gemigliptin inhibited ER-stress induced apoptosis in cardiomyocytes.•Gemigliptin reduced the expression of inflammatory cytokines in cardiomyocytes.•Gemigliptin activated Akt and gemiglitpin-induced inhibition of apoptosis and inflammatory reactions was Akt dependent.