Low concentrations of recombinant granulocyte macrophage-colony stimulating factor derived from Chinese hamster ovary cells augments long-term bioactivity with delayed clearance in vitro.

Atsushi Hashimoto,Takahiro Tanaka,Yuko Itoh,Akira Yamagata,Nobutaka Kitamura,Ryushi Tazawa,Kazuhide Nakagaki,Koh Nakata

Cytokine（2014）

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摘要

•Role of sialic acid residues in the bioactivity of GM-CSF.•Comparison of recombinant human GM-CSF derived from cells of three species.•Sialylated oligosaccharide moieties prolong the bioactivity of rhGM-CSF in vitro.

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关键词

GM-CSF,TF-1 cells,CHO cells,Sialic acid,Oligosaccharide

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