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MicroRNA-9 regulates neural apoptosis in methylmalonic acidemia via targeting BCL2L11

Yanfei Li,Tao Peng,Lin Li,Xiaohan Wang,Ranran Duan,Huili Gao,Wenjuan Guan,Jingjing Lu,Junfang Teng,Yanjie Jia

International Journal of Developmental Neuroscience（2014）

Cited 25|Views48
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Abstract
•We confirm miR-9 suppresses neuronal apoptosis induced by methylmalonate.•MiR-9 specifically reduces the expression level of BCL2L11.•MiR-9 reduced neuronal apoptosis in MMA via targeting BCL2L11.•The expression of miR-9 in neurons with the methylmalonate treatment is down-regulated.
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Key words
MicroRNA-9,BCL2L11,Apoptosis,Methylmalonic acidemia
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