Protective role of peroxisome proliferator-activated receptor β/δ in acute lung injury induced by prolonged hyperbaric hyperoxia in rats.
Respiratory Physiology & Neurobiology（2014）
Abstract
•PPAR-β/δ activation has a protective role against lung injury induced by HBO2.•GW0742 decreases inflammatory mediators and apoptosis in lungs after HBO2 exposure.•GW0742 elevates antioxidant enzyme activities after HBO2 exposure.•GW0742 reduces NF-κB activation and ERK1/2 phosphorylation after HBO2 exposure.
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Key words
Pulmonary oxygen toxicity,Peroxidase proliferator-activated receptor,Inflammation,Apoptosis
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