PI(4,5)P2 produced by the PI4P5K SKTL controls apical size by tethering PAR-3 in Drosophila epithelial cells.

Sandra Claret,Julie Jouette,Béatrice Benoit,Kevin Legent,Antoine Guichet

Current Biology（2014）

引用 69|浏览5

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摘要

•PI(4,5)P2 is crucial to maintain apical-basal polarity•PI(4,5)P2 is regulated by the PI4P5 kinase SKTL but not by the phosphatase PTEN•PI(4,5)P2 controls the targeting of Bazooka/PAR-3 to the apical plasma membrane•PI(4,5)P2 is apically excluded, and BAZ diffuses laterally upon cell invagination

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