Chronic wasting disease agents in nonhuman primates.

Brent Race,Kimberly D Meade-White,Katie Phillips,James Striebel,Richard Race,Bruce Chesebro

EMERGING INFECTIOUS DISEASES（2014）

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摘要

Chronic wasting disease, a prion disease of cervids, may infect humans, but this is unproven. Primates from 2 genera were observed for 9-10 years after intracerebral or oral inoculation. Cynomologus macaques were completely resistant. However, squirrel monkeys were highly susceptible to the pathogen, which adapted more quickly on second passage.

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关键词

chronic wasting disease,cynomolgus macaque,non-human primate,prion,species barrier,squirrel monkey,transmissible spongiform encephalopathy,transmission

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