Chemical constituents from the leaves of Juglans mandshurica

Two new ( 1 and 3 ) and two known diarylheptanoids ( 2 and 4 ), along with two tetralones ( 5 and 6) , one naphthoquinone ( 7 ), four phenylpropanoids ( 8 – 11 ), and one phenol ( 12 ) were isolated from the leaves of Juglans mandshurica . Their structures were elucidated on the basis of spectral and chemical data. Compounds 2 and 10 are firstly isolated from this plant and 8 and 12 were isolated from the Juglans genus for the first time. Among these compounds, only 7 exhibited moderate cytotoxicities against cultured MGC-803, A549, K562, and HeLa tumor cell lines with IC 50 values of 25.90, 28.60, 39.06, 44.90 μM, respectively.