Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells.
Biochemical and Biophysical Research Communications（2014）
Abstract
•Glucagon inhibits insulin signaling via PKA in hepatic cells.•PKA mediates inhibitory phosphorylation of AMPK at Ser173.•Metformin increases AKT activation via inhibition of PKA signaling.•Reciprocal phosphorylation of AMPK mediates insulin resistance.
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Key words
AICAR,AMPK,IRS,PKA,pAKT
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