Valproic acid selectively suppresses the formation of inhibitory synapses in cultured cortical neurons.

Emi Kumamaru,Yoshihiro Egashira,Rie Takenaka,Shigeo Takamori

Neuroscience Letters（2014）

引用 31|浏览1

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摘要

•Exposure of valproic acid to cultured cortical neurons decreased VGAT expression.•The reduction of VGAT by valproic acid was through its HDAC inhibition activity.•Valproic acid suppressed the formation of inhibitory synapses.•Valproic acid may disturb the brain development.

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关键词

Valproic acid,Vesicular GABA transporter,Synapse formation

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