Bis(2,2,2-trifluoroethyl) carbonate as a condensing agent in one-pot parallel synthesis of unsymmetrical aliphatic ureas.
ACS combinatorial science(2014)
摘要
One-pot parallel synthesis of unsymmetrical aliphatic ureas was achieved with bis(2,2,2-trifluoroethyl) carbonate. The procedure worked well for both the monosubstituted and functionalized alkyl amines and required no special conditions (temperature control, order, or rate of addition). A library of 96 diverse ureas was easily synthesized.
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关键词
bis(2,2,2-trifluoroethyl)carbonate,functionalized amines,unsymmetrical aliphatic ureas,one-pot approach,parallel synthesis
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