Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors.

Erchang Shang,Ying Liu,Yiran Wu,Wei Zhu,Chong He,Luhua Lai

Bioorganic & Medicinal Chemistry（2014）

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摘要

In the present work, 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors were developed. Twenty derivatives were designed and synthesized. Several of them were found with significantly increased activity according to cell-free assay and human whole blood assay. The structure–activity relationship study may provide useful insights for designing effective 5-LOX inhibitors.

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