Mir-23b and miR-130b expression is downregulated in pituitary adenomas.

Vincenza Leone,Concetta Langella,Daniela D'Angelo,Paula Mussnich,Anne Wierinckx,Luigi Terracciano,Gerald Raverot,Joel Lachuer,Sandra Rotondi,Marie-Lise Jaffrain-Rea,Jacqueline Trouillas,Alfredo Fusco

Molecular and Cellular Endocrinology（2014）

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摘要

•Here we investigated the role of miR-23b and miR-130b in pituitary carcinogenesis.•miR-23b and miR-130b are reduced in pituitary adenomas of different histotype.•miR-23b and miR-130b target HMGA2 and cyclin A2 (CCNA2) genes, respectively.•HMGA2 and cyclin A2 (CCNA2) play a critical role in pituitary tumorigenesis.

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关键词

microRNA,Pituitary adenoma,HMGA2,CCNA2

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