Protein kinase Cδ contributes to phenylephrine-mediated contraction in the aortae of high fat diet-induced obese mice.

Limei Liu,Jian Liu,Yuansheng Gao,Xiaoxing Yu,Dou Dou,Yu Huang

Biochemical and Biophysical Research Communications（2014）

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摘要

•Expression and activity of IP3 receptor were lost in obese mouse aortae.•PKC pathway was impaired in the aortae of obese mice.•PKCδ is likely to contribute to phenylephrine-induced contraction in obese mouse aortae.

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关键词

α-Adrenoceptor,Inositol 1,4,5-trisphosphate (IP3) receptor,Protein kinase C,Aorta,Obesity

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