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Structures of the Leishmania infantum polymerase beta.

Edison Mejia,Matthew Burak,Ana Alonso,Vicente Larraga,Thomas A Kunkel,Katarzyna Bebenek,Miguel Garcia-Diaz

DNA Repair（2014）

Cited 5|Views5
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Abstract
•The first crystal structure of Li Pol β.•Li Pol β adopts the common family X DNA polymerase fold.•A nonconserved, variable loop (loop3) in Li Pol β interacts with the template strand.•Δloop3 mutants display a higher catalytic rate and overall mutation frequency.
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Key words
DNA repair,Leishmaniasis,DNA polymerase,Family X
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