Tolerance induction between two different strains of parental mice prevents graft-versus-host disease in haploidentical hematopoietic stem cell transplantation to F1 mice.

Yixian Guo,Lanfang Zhang,Suigui Wan,Xuejing Sun,Yongxia Wu,Xue-Zhong Yu,Chang-Qing Xia

Biochemical and Biophysical Research Communications（2014）

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摘要

•Injection of UVB-irradiated iDCs induces alloantigen tolerance.•This alloantigen tolerance may be associated regulatory T cell induction.•Tolerant mice serve as bone marrow donors reduces GVHD to their F1 recipients in allo-HSCT.•Tolerance is maintained in F1 recipients for long time post HSCT.

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关键词

Haploidentical,Hematopoietic stem cell transplantation,Immune tolerance,Graft-versus-host disease,Dendritic cells,Regulatory T cells

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