The alternative splicing side of cancer.

•We provide examples of deregulation of alternative splicing profiles associated with cancer.•We discuss the reciprocal influences between signal transduction pathways and alternative splicing.•We examine the role of splicing factor SRSF1 in cancer.•We review the involvement of alternative splicing in the epithelial to mesenchymal transition, which is required for metastases formation.•We describe the impact of chromatin organization on splicing programs.