A direct access to bioactive fused N-heterocyclic acetic acid derivatives.

Raju Adepu,A Rajitha,Dipali Ahuja,Atul Kumar Sharma,B Ramudu,Ravikumar Kapavarapu,Kishore V L Parsa,Manojit Pal

ORGANIC & BIOMOLECULAR CHEMISTRY（2014）

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摘要

A Cu-catalyzed new sequence involving the Ullmann type intermolecular C-C followed by an intramolecular C-N coupling and then intramolecular aza-Michael type addition (and oxidation) in a single pot afforded various fused N-heterocyclic acetic acid derivatives as inhibitors of PDE4.

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关键词

Directed C–H Functionalization

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