Establish and verify TSH reference intervals using optimized statistical method by analyzing laboratory-stored data
Journal of endocrinological investigation(2014)
Abstract
Objective To establish reference intervals using an optimized statistical method by collecting available laboratory data of thyroid stimulating hormone (TSH), and then to verify with the laboratory-present reference intervals. Methods TSH RIs of the total population and different races, genders, age, source of sample are established through improved Hoffmann and Katayev’s method with TSH test results data from Jan 2010 to April 2012 were collected, and finally conduct comparative verification with the laboratory present RIs. Results According to the improved method, we get various RIs of different sample populations. On comparing with the laboratory current RI (0.270–4.200 mIU/L) most reference change values (RCV) were within acceptable limits. Only lower limit of Han male, Uygur male and out-patient male populations outwith acceptable limits. On excluding the different values, finally, the new RI by the optimized statistical method is 0.233–4.979 mIU/L. Because the new RI expanded the current RI and was not different from the current RI, it was indicated that new RI could be used to verify the laboratory current RIs and seen as the current RI’s confidence interval (CI). Inference TSH RIs established by optimized Hoffmann’s and Katayev’s methods is viable and can be used to verify RIs provided by manufacturers or other laboratories.
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Key words
Reference intervals,Thyroid stimulating hormone,Verification
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