Non-intercalative and sequence-selective interaction of nitropyrene/acridine-skeleton with nucleotides: application of the dextran-coupling method.

Water-insoluble typical intercalators, acridine and pyrene, were converted to water-soluble species, Dex-pyr and Dex-Acr, respectively, by coupling with dextran polymer. By the use of these dextran-coupled intercalators, interactions of acridine- and pyrene-skeletones with various nucleotides in aqueous solutions were analyzed.