Long-lasting HHV-6 reactivation in long-term adult survivors after double umbilical cord blood allogeneic stem cell transplantation.

Marina Illiaquer, Florent Malard, Thierry Guillaume,Berthe-Marie Imbert-Marcille,Jacques Delaunay,Amandine Le Bourgeois,Marie Rimbert,Celine Bressollette-Bodin,Cristina Precupanu,Sameh Ayari,Pierre Peterlin,Philippe Moreau,Mohamad Mohty,Patrice Chevallier

JOURNAL OF INFECTIOUS DISEASES（2014）

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摘要

Higher incidence of human herpesvirus 6 (HHV-6) infection has been documented after umbilical cord blood allo-transplant in adults. Here we demonstrate that HHV-6 reactivation persists for a very long time in half of the patients after this type of graft. Long-term immune reconstitution does not explain this event, which remains to be explained.

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关键词

adults,allo-SCT,cord blood,HHV-6,immune reconstitution,PBSC

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