RTEL1: functions of a disease-associated helicase.

Jean-Baptiste Vannier,Grzegorz Sarek,Simon J Boulton

Trends in Cell Biology（2014）

引用 98|浏览9

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摘要

•RTEL1 is an Fe–S helicase that controls homologous recombination by dismantling D-loop intermediates.•RTEL1 maintains telomere integrity by disassembling T-loops and counteracting G4-DNA structures.•RTEL1 variants strongly associate with predisposition to glioma, astrocytoma, and glioblastoma.•Mutations in RTEL1 give rise to Hoyeraal–Hreidarsson syndrome.

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关键词

telomeres,Hoyeraal–Hreidarsson syndrome,DNA repair,homologous recombination,double-strand break repair,DNA replication

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