Synthesis of taurine-containing peptides, sulfonopeptides, and N- and O-conjugates.
JOURNAL OF ORGANIC CHEMISTRY(2014)
摘要
Taurine-containing water-soluble peptidomimetics were designed and synthesized. N-terminal taurine acylations allowed synthesis of a number of taurine-containing peptides. N-protection of taurine with Cbz and SO2-activation with benzotriazole followed by coupling with various amino esters, dipeptides and nucleophiles provided taurine N- and O-conjugates and sulfonopeptides.
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关键词
sulfonopeptides,peptides,synthesis,taurine-containing,o-conjugates
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