Chemotherapy-induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia.

Franz J Gassner,Nadja Zaborsky,Daniel Neureiter,Michael Huemer,Thomas Melchardt,Alexander Egle,Stefan Rebhandl,Kemal Catakovic,Tanja N Hartmann,Richard Greil,Roland Geisberger

HAEMATOLOGICA（2014）

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摘要

While T-cell dysfunction occurring alongside chronic lymphocytic leukemia (CLL) is well documented (reviewed by Pleyer et al. [1][1] and Hamblin et al. [2][2]), it was recently reported that also T-cell exhaustion is associated with CLL, reflected in the presence of PD-1+ CLL T cells and higher

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关键词

chronic lymphocytic leukemia,lenalidomide,T cell imhibitory receptors

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