CD2 and CD8α define porcine γδ T cells with distinct cytokine production profiles.

•Only CD2− γδ T cells with a rare CD8α+CD27− phenotype produced IL-17A.•Within CD2+ γδ T cells IFN-γ producing cells strongly dominated.•IFN-γ/TNF-α co-producing γδ T cells had a distinct CD2+CD8α+CD27− phenotype.•CD2 and CD8α expression correlates with distinct cytokine production profiles.