Enhanced Feeding And Diminished Postnatal Growth Failure In Very-Low-Birth-Weight Infants

Objective:The aim of the present study was to determine whether an increased supply of energy, protein, essential fatty acids, and vitamin A reduces postnatal growth failure in very-low-birth-weight infants.Methods:Fifty infants with birth weight <1500 g were randomized to an intervention (n=24) or a control (n=26) feeding protocol within 24 hours after birth. Forty-four infants were included in the final analysis. This study was discontinued because of an increased occurrence of septicemia in the intervention group.Results:The intervention group had a lower mean birth weight (P=0.03) and a higher proportion of infants small-for-gestational age (P=0.04) than the control group. Other baseline characteristics were similar. The median (interquartile range) energy and protein supplies during the first 4 weeks of life were higher in the intervention group: 139 (128-145) versus 126 (121-128) kcal kg(-1) day(-1) (P<0.001) and 4.0 (3.9-4.2) versus 3.2 (3.1-3.3) g kg(-1) day(-1) (P<0.001). The infants in the intervention group regained birth weight faster (P=0.001) and maintained their z scores for weight and head circumference from birth to 36 weeks' postmenstrual age (both P<0.001). The median (interquartile range) growth velocity was 17.4 (16.3-18.6) g kg(-1) day(-1) in the intervention group and 13.8 (13.2-15.5) g kg(-1) day(-1) in the control group (P<0.001). In line with the improved growth in the intervention group, the proportion of growth-restricted infants was 11 of 23 both at birth and at 36 weeks' postmenstrual age, whereas this proportion increased among the controls from 4 of 21 to 13 of 21 (P=0.04).Conclusions:Enhanced supply of energy, protein, essential fatty acids, and vitamin A caused postnatal growth along the birth percentiles for both weight and head circumference.