Low serum level of secreted frizzled-related protein 5, an anti-inflammatory adipokine, is associated with coronary artery disease.

•The serum level of SFRP5 in patients with CAD was significantly lower than that in patients with CAD.•The serum level of SFRP5 was negatively correlated with body mass index, insulin resistance, and the severity of CAD.•Multivariate analysis revealed that the low level of serum SFRP5 was independently associated with the presence of CAD.•Sub-analysis on the basis of age showed that this association was significant for subjects who were <65 years old.