How Trypanosoma cruzi handles cell cycle arrest promoted by camptothecin, a topoisomerase I inhibitor.

Aline Araujo Zuma,Isabela Cecília Mendes,Lissa Catherine Reignault,Maria Carolina Elias,Wanderley de Souza,Carlos Renato Machado,Maria Cristina M Motta

Molecular and Biochemical Parasitology（2014）

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摘要

•Inhibition of cell proliferation was reversible with the lowest drug concentration.•Camptothecin caused parasite cell cycle arrest at late S/G2/M.•Cell cycle arrest is related to nuclear DNA damage.•Parasites entered in early apoptosis but do not progress to late apoptosis.

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关键词

Apoptosis,Camptothecin,Cell cycle,Topoisomerase inhibitors,Ultrastructure,Trypanosoma cruzi

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