Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions.

ENZYME KINETICS IN DRUG METABOLISM: FUNDAMENTALS AND APPLICATIONS（2021）

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摘要

This chapter describes the types of irreversible inhibition of drug-metabolizing enzymes and the methods commonly employed to quantify the irreversible inhibition and subsequently predict the extent and time course of clinically important drug-drug interactions.

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关键词

Drug–drug interaction,Enzyme inactivation,Heme,IC50 shift,Mechanism-based inhibition,Metabolite intermediate complex,Suicide inhibition,Time-dependent inhibition

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